Chemistry of Jardiance(Empagliflozin)

Chemical Name:D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3furanyl]oxy]phenyl]methyl]phenyl]- (1S)

Molecular Forumula : C23H27CLO7

Molecular weight: 450.91

Chemical Structure:

Appearance:White to Yellowish,non-hygroscopic powder

Solubility:Soluble in water,sparingly soluble in methanol,slightly soluble in Ethanol and Acetonitrile,soluble in 50% acetonitile/water,practically insoluble in Toluene.

Jardiance(Empagliflozin) , new Type-2 antidiabetic drug block by NICE in UK

Empagliflozin , marketed as Jardiance  is a drug used in treatment of type-2 diabetes which acts by inhibiting Sodium Glucose co-transporter  (DGLT-2) .This drug blocks the reabsorbption of glucose in kidneys and hence pass out of the body in urine.it is administered through oral route and once-daily medication.
NICE ,  National Institute for Health and Care Excellence rebuffed ,asked  Boehringer  for new analysis and comparisons with available treatments and revised look at cost -effectiveness.According to NICE there is a good evidence to show Empagliflozin is clinically effective in type-2 diabetes but there is a need for more inforamtion to demonstrate its cost -effectiveness when compared with other treatments that NHS already provides.
On the other hand in United States , Jardiance already hits stores .Eli Lilly and Boehringer Ingelheim are the manufacturers of Jardiance.

More :Chemistry of Jardiance(empagliflozin)